Dicarboxylic acids and derivatives
Medchemexpress LLC ULK-101 1mg | 2443816-45-1 | 1 MG
ULK-101 is a potent, selective small-molecule inhibitor of ULK1 (unc-51-like autophagy activating kinase 1) that suppresses autophagy and can sensitize cancer cells to nutrient stress. It is supplied as a research-grade solid for in vitro studies.
- Potent ULK1 inhibition; reported low-nanomolar IC50 for ULK1, ULK2 ~30 nM
- Suppresses autophagy and sensitizes cancer cells to nutrient stress
- Molecular formula C22H16F4N4OS and molecular weight ~460.4 g/mol
- Provided as a 1 mg quantity suitable for assay development and biochemical studies
![Medchemexpress LLC O=C([C@]1(CO1)CO[Si](C)(C)C(C)(C)C)[C@H](CC(C)C)NC([C@H](C)NC(CCCCCC)=O)=O | 1000313-40-5 | 99.6% | 484.74 | C25H48N2O5Si | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000229462.png-250.jpg)
Medchemexpress LLC O=C([C@]1(CO1)CO[Si](C)(C)C(C)(C)C)[C@H](CC(C)C)NC([C@H](C)NC(CCCCCC)=O)=O | 1000313-40-5 | 99.6% | 484.74 | C25H48N2O5Si | 5 MG
UK-101 is a selective immunoproteasome β1i (LMP2) inhibitor for laboratory research. It shows reported potency with an IC50 of about 104 nM and is supplied as a high-purity solid suitable for in vitro studies; recommended solvent is DMSO.
- Selective immunoproteasome β1i (LMP2) inhibitor with IC50 ≈104 nM.
- High purity (≈99.6%).
- Available in small research quantities, e.g., 5 mg.
- Recommended solvent: DMSO for dissolution.
- Powder storage: -20°C (3 years) or 4°C (2 years); solutions: -80°C (6 months).
- For research use only; not for human or clinical use.
Medchemexpress LLC UK-101 | 1000313-40-5 | 99.6% | 484.74 g/mol | C25H48N2O5Si | 25 MG
UK-101 is a potent, selective immunoproteasome β1i (LMP2) inhibitor intended for research use. It has a reported IC50 of 104 nM against LMP2, with significant selectivity over the constitutive β1c and β5 proteasome subunits. UK-101 is used in cell-based studies to induce apoptosis and to investigate immunoproteasome function and cancer-related pathways. Supplied as a powder with recommended storage conditions to preserve stability.
- Potent LMP2 (β1i) inhibitor with IC50 ≈ 104 nM.
- Selective over proteasome β1c and β5 subunits.
- Induces apoptosis in cell-based assays.
- High purity suitable for biochemical and cellular studies.
- Supplied as powder with recommended storage for long-term stability.
Selleck Chemical LLC MG-101
MG-101 (ALLN Calpain inhibitor-1 Ac-LLnL-CHO) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins
Medchemexpress LLC Lauroyl-L-carnitine-d9 chloride | 2245711-25-3 | MFCD34676545 | 98.0% | 389.02 g/mol | C19H29D9ClNO4 | 5 MG
Lauroyl-L-carnitine-d9 chloride is the deuterium-labeled chloride salt of lauroyl-L-carnitine supplied for analytical and tracer applications. It is intended for use as a stable-isotope internal standard in bioanalytical, pharmacokinetic, and tracer studies where mass spectrometry differentiation is required.
- Stable isotope labeled internal standard for mass spectrometry
- Deuterated (d9) for clear mass separation from native compound
- High purity (98.0%) suitable for analytical workflows
- Chloride salt form for compatibility with common assays
- Supplied in a 5 mg quantity for small-scale analyses
Medchemexpress LLC Lauroyl-L-carnitine chloride | 6919-91-1 | MFCD00274131 | 98.1% | C19H38ClNO4 | 10MG
Lauroyl-L-carnitine chloride is an orally active absorption enhancer used in research to improve the oral bioavailability of peptide compounds. Supplied as a white to off-white solid with high purity, it is applied in formulation and permeability studies to assess and enhance intestinal uptake of peptide drugs.
- Orally active absorption enhancer for peptide compounds.
- Reported to improve oral bioavailability of peptides.
- White to off-white solid suitable for formulation research.
- High purity (~98.1%) as supplied.
- Supports studies of intestinal permeability and delivery.
- Store sealed at 4°C; in solvent, -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC Lei 101 hydrochloride | 2250025-91-1 | 508.99 g/mol | 50mg
LEI-101 is a potent selective and orally bioavailable cannabinoid CB2 receptor agonist with a pEC50 of 8 for hCB2 and a pKi of less than 4 for hERG LEI-101 is 100-fold more potent in binding to CB2 receptors than to CB1 receptors[1][2]
Medchemexpress LLC PKUMDL-LC-101-D04 100mg | 2143896-83-5 | 378.9 | C14H22N4O2S2 · HCl | 100 MG
PKUMDL-LC-101-D04 (GPX4-Activator-1d4) is a small-molecule allosteric activator of glutathione peroxidase 4 (GPX4) used in research to modulate ferroptosis and lipid-peroxide-mediated cell death. It increases GPX4 enzymatic activity in biochemical assays and has demonstrated activity in cell extracts and cellular protection assays.
- Allosteric activator of glutathione peroxidase 4.
- Increases GPX4 activity to about 150% in a cell-free assay at 20 μM.
- Restores GPX4 activity in cell extracts at 61 μM.
- Reduces cholesterol hydroperoxide-induced cell death in mouse embryonic fibroblasts.
- High purity research-grade material suitable for biochemical and cellular assays.
- Molecular weight 378.9 and formula C14H22N4O2S2 · HCl.
Selleck Chemical LLC GlyH-101
GlyH-101 is a selective and reversible CFTR inhibitor with Ki of 4 3 M
Medchemexpress LLC VH 101, acid | 2408341-97-7 | 98.8% | 574.66 | C28H35FN4O6S | 10 MG
VH 101, acid is a functionalized von Hippel-Lindau (VHL) E3 ligase ligand developed for PROTAC research and conjugation chemistry. The molecule includes an E3 ligase recognition motif and an alkyl linker terminating in a primary amine, facilitating attachment to target protein ligands.
- Designed for use as a VHL E3 ligase ligand in PROTAC development.
- Alkyl linker with terminal amine enables straightforward conjugation chemistry.
- High reported purity suitable for research applications.
- Supplied in small research-scale quantities for synthetic work and assay testing.
Medchemexpress LLC 1,2-dilauroyl-sn-glycero-3-phosphoethanolamine | 59752-57-7 | MFCD00042828 | 98.0% | 579.75 g·mol⁻¹ | C29H58NO8P | 100 MG
1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine (DLPE) is a phosphatidylethanolamine derivative bearing two lauroyl (C12:0) acyl chains. It is a research-grade lipid commonly used for liposome formulation and membrane model studies; typical properties include a molecular weight of 579.75 g·mol⁻¹ and high purity (98.0%).
- Phosphatidylethanolamine lipid with two lauroyl (C12:0) chains.
- Suitable for liposome synthesis and membrane model studies.
- High purity (98.0%) for research applications.
- Molecular formula C29H58NO8P and molecular weight 579.75 g·mol⁻¹.
Medchemexpress LLC AVN-101 hydrochlorid 10mg | 1061354-48-0 | 340.89 | C21H25ClN2 | 10 MG
AVN-101 hydrochloride is the hydrochloride salt of AVN-101, a brain-penetrant, orally active antagonist of serotonin 5-HT7 receptors used in preclinical CNS research. It is supplied as a high-purity solid for in vitro and in vivo studies.
- Potent 5-HT7 receptor antagonist with additional activity at 5-HT6, 5-HT2A, 5-HT2C, H1, and α2 adrenergic receptors.
- Brain-penetrant and orally active, suitable for CNS pharmacology studies.
- High purity solid (LCMS purity 99.59%) for reliable experimental results.
- Chemical identity: 1H-pyrido[4,3-b]indole hydrochloride; formula C21H25ClN2; Mw 340.89.
- Recommended storage: sealed at -20°C; solvent storage guidance available from supplier.
Selleck Chemical LLC MZ-101-E1913-5MG
MZ-101 (GYS1-IN-2) is a potent small molecule inhibitor of Glycogen synthase 1(GYS1) with an IC50 value of 0 041 M By depleting muscle glycogen MZ-101 treatment normalizes glycogen levels and corrects transcriptional and metabolic abnormalities in Pompe mice
![Medchemexpress LLC N-(2-(1H-indol-3-yl)ethyl)-5-(5-fluoropyridin-3-yl)-3-methylpyrazolo[1,5-a]pyrimidin-7-amine | 2247950-73-6 | 98.0% | C22H19FN6 | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000261386.png-250.jpg)
Medchemexpress LLC N-(2-(1H-indol-3-yl)ethyl)-5-(5-fluoropyridin-3-yl)-3-methylpyrazolo[1,5-a]pyrimidin-7-amine | 2247950-73-6 | 98.0% | C22H19FN6 | 10MG
KYN-101 is a small-molecule, selective, orally active antagonist of the aryl hydrocarbon receptor (AHR) supplied for laboratory research. It reduces CYP1A1 mRNA expression and has demonstrated anti-cancer activity in preclinical studies, making it suitable for mechanistic studies of AHR signaling and oncology research.
- Selective AHR inhibition with reported nanomolar potency.
- Orally active in preclinical models.
- Reduces CYP1A1 mRNA expression in cellular assays.
- Useful for mechanistic studies of AHR signaling and cancer biology.
- Available as solid and ready-to-use DMSO solutions for assay setup.
- High purity suitable for research applications.
Medchemexpress LLC Vnt-101 | 2894060-67-2 | 456.41 | C21H23F3N2O6 | 10 MG
VNT-101 is a small-molecule, orally active inhibitor of influenza A virus nucleoprotein (NP) oligomerization. It disrupts NP-NP protein-protein interactions to destabilize the viral ribonucleoprotein complex and has been used in vitro and in vivo to study antiviral activity across multiple influenza A subtypes.
- Disrupts nucleoprotein oligomerization to inhibit viral replication.
- Orally bioavailable small molecule suitable for in vivo studies.
- Demonstrated activity against multiple influenza A subtypes.
- Molecular weight 456.41 and molecular formula C21H23F3N2O6.
- CAS number 2894060-67-2 for substance identification.
- Supplied as a solid for research use with supporting characterization data.